Polycomb Group Transcriptional Repressor: Suppress to Sustain
نویسندگان
چکیده
منابع مشابه
Sumo Modification Impedes Transcriptional Silencing by the Polycomb Group Repressor Sex Comb on Midleg
The Drosophila protein Sex Comb on Midleg (Scm) is a member of the Polycomb group (PcG), a set of transcriptional repressors that maintain silencing of homeotic genes during development. Recent findings have identified PcG proteins both as targets for modification by the ubiquitin-like protein SUMO and as catalytic components of the SUMO conjugation pathway. We have found that the SUMO conjugat...
متن کاملTranscriptional silencing by polycomb-group proteins.
Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable transcriptional silencing. PcG proteins participate in distinct multimeric complexes that deposit, or bind to, specific histone modifications (e.g., H3K27me3 and H2AK119ub1) to prevent gene activation and maintain repressed chromatin domains. PcG proteins are evolutionary conserved and play a role in processes...
متن کاملHistone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
Polycomb group (PcG) proteins maintain transcriptional repression during development, likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of Zeste [E(Z)] proteins are partners in an essential PcG complex, but its full composition and biochemical activities are not known. A SET domain in E(Z) suggests this complex might methylate histones. We purified an ESC-E(...
متن کاملThe Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor
The Polycomb and trithorax groups of genes control the maintenance of homeotic gene expression in a variety of organisms. A putative participant in the regulation of this process is the murine RYBP (Ring and YY1 Binding Protein) gene. Sequence comparison between different species has identified the homologous gene in Drosophila, the dRYBP gene. We have investigated whether dRYBP participates in...
متن کاملRET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.
RET finger protein (RFP) belongs to the large B-box RING finger protein family and is known to become oncogenic by fusion with RET tyrosine kinase. Although RFP is reported to be a nuclear protein that is present in the nuclear matrix, its function is largely unknown. Here we show that RFP interacts with Enhancer of Polycomb (EPC) and strongly represses the gene transcription. Yeast two-hybrid ...
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ژورنال
عنوان ژورنال: Plant Physiology
سال: 2018
ISSN: 0032-0889,1532-2548
DOI: 10.1104/pp.18.00975